Christina Applegate Tested for Other Diseases After MS Misdiagnosis

Christina Applegate has opened up about a frustrating new chapter. Speaking on her MeSsy podcast, the actress said she is back to square one after learning her multiple sclerosis diagnosis was wrong, and she is now being tested one by one for what she calls the sister diseases of MS.

Applegate named rheumatoid arthritis, lupus and Lyme disease as conditions that can mimic MS, saying she is being checked for all of them slowly but surely. She revealed her original MS diagnosis in 2021, and TMZ notes she announced in October 2026 that she had been misdiagnosed. The details make for compelling reading.

She also described an identity crisis, explaining that she feels like a fraud after years of being known for living with MS. Her candour has struck a chord with fans who have followed her health journey, and many are now waiting to hear what the remaining tests reveal. More updates are expected soon.